Diagnóstico y tratamiento actual de la gastroparesia: una revisión sistemática de la literatura
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https://doi.org/10.22516/25007440.561Palabras clave:
Vaciamiento gástrico, gastroparesia, dismotilidad gástricaResumen
El vaciamiento gástrico normal refleja un esfuerzo coordinado entre diferentes regiones del estómago y el duodeno, y también una modulación extrínseca por parte del sistema nervioso central y factores del intestino distal. Los principales eventos relacionados con el vaciamiento gástrico normal incluyen el fondo de relajación para acomodar la comida, contracciones antrales para triturar partículas grandes de comida, contracción pilórica para permitir la liberación de comida del estómago y coordinación antropiloroduodenal de los fenómenos motores de relajación. La dismotilidad gástrica incluye el vaciamiento tardío del estómago (gastroparesia), vaciamiento gástrico acelerado (síndrome de dumping) y otras disfunciones motoras, como el deterioro del fondo de distensión, que se encuentra con mayor frecuencia en la dispepsia funcional. Los síntomas de la gastroparesia son inespecíficos y pueden simular otros trastornos estructurales.
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Referencias bibliográficas
Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L; American College of Gastroenterology. Clinical guideline: management of gastroparesis. Am J Gastroenterol. 2013;108(1):18-37; quiz 38.
https://doi.org/10.1038/ajg.2012.373
Tack J, Carbone F, Rotondo A. Gastroparesis. Curr Opin Gastroenterol. 2015;31(6):499-505.
https://doi.org/10.1097/MOG.0000000000000220
Farre R, Tack J. Food and symptom generation in functional gastrointestinal disorders: physiological aspects. Am J Gastroenterol. 2013;108(5):698-706.
https://doi.org/10.1038/ajg.2013.24
Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol. 2003;98(4):783-8.
https://doi.org/10.1111/j.1572-0241.2003.07389.x
Jones KL, Russo A, Stevens JE, Wishart JM, Berry MK, Horowitz M. Predictors of delayed gastric emptying in diabetes. Diabetes Care 2001;24(7):1264-9.
https://doi.org/10.2337/diacare.24.7.1264
Hoogerwerf WA, Pasricha PJ, Kalloo AN, Schuster MM. Pain: the overlooked symptom in gastroparesis. Am J Gastroenterol 1999;94(4):1029-33.
https://doi.org/10.1111/j.1572-0241.1999.01008.x
Søfteland E, Brock C, Frøkjær JB, Simrén M, Drewes AM, Dimcevski G. Rectal sensitivity in diabetes patients with symptoms of gastroparesis. J Diabetes Res 2014; 2014:784841.
https://doi.org/10.1155/2014/784841
Bharucha AE, Batey-Schaefer B, Cleary PA, Murray JA, Cowie C, Lorenzi G, Driscoll M, Harth J, Larkin M, Christofi M, Bayless M, Wimmergren N, Herman W, Whitehouse F, Jones K, Kruger D, Martin C, Ziegler G, Zinsmeister AR, Nathan DM; Diabetes Control and Complications Trial–Epidemiology of Diabetes Interventions and Complications Research Group. Delayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes Mellitus. Gastroenterology. 2015;149(2):330-9.
https://doi.org/10.1053/j.gastro.2015.05.007
Stanghellini V, Tack J. Gastroparesis: separate entity or just a part of dyspepsia? Gut. 2014;63(12):1972-1978.
https://doi.org/10.1136/gutjnl-2013-306084
Stacher G, Lenglinger J, Bergmann H, Schneider C, Hoffmann W, Wol-fl G, Stacher-Janotta G. Gastric emptying: a contributory factor in gastrooesophageal reflux activity? Gut 2000;47(5):661-6.
https://doi.org/10.1136/gut.47.5.661
Barnert JRA, Dumitrascu DL, Wienbeck M. Gastroesophageal reflux disease: emptying of the proximal and the distal stomach measured by ultrasonography Gastroenterology. 2001;120(5 Suppl 1):A460.
https://doi.org/10.1016/S0016-5085(08)82281-0
Lee H-R, Lennon VA, Camilleri M, Prather CM. Paraneoplastic gastrointestinal motor dysfunction: clinical and laboratory characteristics. Am J Gastroenterol. 2001;96(2):373-9.
https://doi.org/10.1111/j.1572-0241.2001.03454.x
Bonapace ES, Davidoff S, Krevsky B, Fisher RS, Parkman HP. Whole gut transit scintigraphy in the clinical evaluation of patients with upper and lower gastrointestinal symptoms. Am J Gastroenterol. 2000;95(10):2838-47.
https://doi.org/10.1111/j.1572-0241.2000.03195.x
Casey KM, Quigley TM, Kozarek RA, Raker EJ. Lethal nature of ischemic gastropathy. Am J Surg. 1993;165 (5):646-9.
https://doi.org/10.1016/S0002-9610(05)80453-2
Brand RE, DiBaise JK, Quigley EM, Gobar LS, Harmon KS, Lynch JC, Bierman PJ, Bishop MR, Tarantolo SR. Gastroparesis as a cause of nausea and vomiting after high-dose chemotherapy and haemopoietic stem-cell transplantation. Lancet. 1998;352(9145):1985.
https://doi.org/10.1016/S0140-6736(05)61330-X
Eagle DA, Gian V, Lauwers GY, Manivel JC, Moreb JS, Mastin S, Wingard JR. Gastroparesis following bone marrow transplantation. Bone Marrow Transplant 2001;28(1):59-62.
https://doi.org/10.1038/sj.bmt.1703084
Chowdhury RS, Forsmark CE, Davis RH, Toskes PP, Verne GN. Prevalence of gastroparesis in patients with small duct chronic pancreatitis. Pancreas. 2003;26(3):235-8.
https://doi.org/10.1097/00006676-200304000-00005
Van Vlem B, Schoonjans R, Vanholder R, De Vos M, Vandamme W, Van Laecke S, Lameire N. Delayed gastric emptying in dyspeptic chronic hemodialysis patients. Am J Kidney Dis. 2000;36(5):962-8.
https://doi.org/10.1053/ajkd.2000.19094
De Schoenmakere G, Vanholder R, Rottey S, Duym P, Lameire N. Relationship between gastric emptying and clinical and biochemical fac- tors in chronic haemodialysis patients. Nephrol Dial Transplant 2001;16(9):1850-5. https://doi.org/10.1093/ndt/16.9.1850
Nowak TV, Goddard M, Batteiger B, Cummings OW. Evolution of acute cytomegalovirus gastritis to chronic gastrointestinal dysmotility in a nonimmunocompromised adult. Gastroenterology 1999;116(4):953-8.
https://doi.org/10.1016/S0016-5085(99)70079-X
Neild PJ, Nijran KS, Yazaki E, Evans DF, Wingate DL, Jewkes R, Gazzard BG. Delayed gastric emptying in human immunodeficiency virus infection. Dig Dis Sci. 2000;45(8):1491-9.
https://doi.org/10.1023/A:1005587922517
Mearin F, de Ribot X, Balboa A, Salas A, Varas MJ, Cucala M, Bartolome R, Armengol JR, Malagelada JR. Does Helicobacter pylori infection increase gastric sensitivity in functional dyspepsia? Gut 1995;37(1):47-51.
https://doi.org/10.1136/gut.37.1.47
Salicru M, Juarez D, Genta RM. Low prevalence of H. pylori infection in patients with gastroparesis. Dig Liver Dis. 2013;45(11):905-8.
https://doi.org/10.1016/j.dld.2013.05.001
Quigley EMM, Hasler W, Parkman HP. AGA technical review on nausea and vomiting. Gastroenterology. 2001;120(1):263-86.
https://doi.org/10.1053/gast.2001.20516
Hornbuckle K, Barnett JL. The diagnosis and work-up of the patient with gastroparesis. J Clin Gastroenterol. 2000;30(2):117-24.
https://doi.org/10.1097/00004836-200003000-00004
Parkman HP. Idiopathic gastroparesis. Gastroenterol Clin North Am. 2015;44(1):59-68.
https://doi.org/10.1016/j.gtc.2014.11.015
Pasricha PJ, Parkman HP. Gastroparesis: definitions and diagnosis. Gastroenterol Clin North Am. 2015;44(1):1-7. https://doi.org/10.1016/j.gtc.2014.11.001
Parkman HP, Harris AD, Krevsky B, Urbain JL, Maurer AH, Fisher RS. Gastroduodenal motility and dysmotility: update on techniques available for evaluation. Am J Gastroenterol. 1995;90(6):869-92.
Galil MA, Critchley M, Mackie CR. Isotope gastric emptying tests in clinical practice: expectation, outcome, and utility. Gut. 1993;34(7): 916-19.
https://doi.org/10.1136/gut.34.7.916
Rahim MK, Durr-E-Sabih, Mateen A, Najam-Uddin, Yousaf M. Studies of gastric emptying time in patients with non-ulcer dyspepsia. Nucl Med Commun. 2007;28(11):852-8.
https://doi.org/10.1097/MNM.0b013e3282f0d167
Tougas GH, Eaker EY, Abell TL, Abrahamsson H, Boivin PL, Chen J, Hocking MP, Quigley EM, Koch KL, Tokayer AZ, Stanghellini V, Chen Y, Huizinga JD, Ryden J, Bourgeois I, McCallum RW. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol 2000;95(6):1456-62. https://doi.org/10.1111/j.1572-0241.2000.02076.x
Guo JP, Maurer AH, Fisher RS, Parkman HP. Extending gastric emptying scintigraphy from two to four hours detects more patients with gastroparesis. Dig Dis Sci. 2001;46(1):24-9.
https://doi.org/10.1023/a:1005697422454
Tomita T, Okugawa T, Yamasaki T, Kondo T, Toyoshima F, Sakurai J, Oshima T, Fukui H, Daimon T, Watari J, Kashiwagi T, Matsumoto T, Miwa H. Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat. J Gastroenterol Hepatol. 2013;28(1):106-11.
https://doi.org/ 10.1111/j.1440-1746.2012.07261.x
Camilleri M, Hasler W, Parkman HP, Quigley EM, Soffer E. Measurement of gastroduodenal motility in the GI laboratory. Gastroenterology. 1998;115(3):747-62.
https://doi.org/10.1016/s0016-5085(98)70155-6
Singla R, Homko C, Schey R, Parkman HP. Diabetes-related autoantibodies in diabetic gastroparesis. Dig Dis Sci. 2015;60(6):1733-1737.
https://doi.org/10.1007/s10620-015-3690-0
Bharucha AE, Kudva Y, Basu A, Camilleri M, Low PA, Vella A, Zinsmeister AR. Relationship between glycemic control & and gastric emptying in poorly controlled type 2 diabetes. Clin Gastroenterol Hepatol. 2015;13(3):466-476; e1. https://doi.org/10.1016/j.cgh.2014.06.034
Bromer MQ, Kantor SN, Wagner DA, Knight LC, Maurer AH, Parkman HP. Simultaneous measurement of gastric emptying with a simple muffin meal using 13C-octanoate breath test and scintigraphy in normal subjects and patients with in dyspeptic symptoms. Dig Dis Sci. 2002;47(7):1657-63.
https://doi.org/10.1023/A:1015856211261
Kim D-Y, Myung S-J, Camilleri M. Novel testing of human gastric motor and sensory functions: Rationale, methods, and potential applications in clinical practice. Am J Gastroenterol 2000;95(12):3365-73.
https://doi.org/10.1111/j.1572-0241.2000.03346.x
Parkman HP, Hasler WL, Barnett JL, Eaker EY; American Motility Society Clinical GI Motility Testing Task Force. Electrogastrography: a document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force. Neurogastroenterol Motil. 2003;15(2):89-102.
https://doi.org/10.1046/j.1365-2982.2003.00396.x
Chen JZ, McCallum Dis RW. Clinical applications of electrogastrography. Am J Gastroenterol 1993;88(9):1324-36.
Barshop K, Staller K, Semler J, Kuo B. Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients. Neurogastroenterol Motil. 2015;27(3):339-346.
https://doi.org/10.1111/nmo.12496
Chen JD, Lin Z, Pan J, McCallum RW. Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms sug- gestive of gastroparesis. Dig Dis Sci. 1996;41(8):1538-45.
https://doi.org/10.1007/BF02087897
Parkman HP, Miller MA, Trate DM, Knight LC, Brown KL, Maurer AH, Fisher RS. Electrogastrography and gastric emptying scintigraphy are complementary for assessment of dyspepsia. J Clin Gastroenterol 1997;24(4):214-9. https://doi.org/10.1097/00004836-199706000-00006
Szarka LA, Camilleri M. Methods for measurement of gastric motility. Am J Physiol Gastrointest Liver Physiol. 2009;296(3):G461-75.
https://doi.org/10.1152/ajpgi.90467.2008
Kim D-Y, Delgado-Aros S, Camilleri M, Samsom M, Murray JA, O’Connor MK, Brinkman BH, Stephens DH, Lighuani SS, Burton DD. Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia. Am J Gastroenterol 2001;96(11):3099-105. https://doi.org/10.1111/j.1572-0241.2001.05264.x
Olausson EA, Störsrud S, Grundin H, Isaksson M, Attvall S, Simrén M. A small particle size diet reduces upper gastrointestinal symptoms in patients with diabetic gastroparesis: a randomized controlled trial. Am J Gastroenterol. 2014;109(3):375-85.
https://doi.org/10.1038/ajg.2013.453
Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol. 2000;95(12):3374-82.
https://doi.org/10.1111/j.1572-0241.2000.03347.x
Miller G, Palmer KR, Smith B, Ferrington C, Merrick MV. Smoking delays gastric emptying of solids. Gut. 1989;30(1):50-3.
https://doi.org/10.1136/gut.30.1.50
Homko CJ, Duffy F, Friedenberg FK, Boden G, Parkman HP. Effect of dietary fat and food consistency on gastroparesis symptoms in patients with gastroparesis. Neurogastroenterol Motil. 2015;27(4):501-8.
https://doi.org/10.1111/nmo.12519
Janssen P, Harris MS, Jones M, Masaoka T, Farré R, Törnblom H, Van Oudenhove L, Simrén M, Tack J. The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am J Gastroenterol. 2013;108(9):1382-91.
https://doi.org/10.1038/ajg.2013.118
Hoogerwerf WA, Pasricha PJ, Kalloo AN, Schuster MM. Pain: the overlooked symptom in gastroparesis. Am J Gastroenterol. 1999;94(4):1029-33.
https://doi.org/10.1111/j.1572-0241.1999.01008.x
Lata PF, Pigarelli DL. Chronic metoclopramide therapy for diabetic gastroparesis. Ann Pharmacother. 2003;37(1):122-6.
https://doi.org/10.1345/aph.1C118
Parkman HP, Carlson MR, Gonyer D. Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. Neurogastroenterol Motil. 2014;26(4):521-528.
https://doi.org/10.1111/nmo.12296
Parkman HP, Carlson MR, Gonyer D. Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not men, with diabetes: results of a phase 2B randomized study. Clin Gastroenterol Hepatol. 2015;13(7):1256-1263; e1.
https://doi.org/10.1016/j.cgh.2014.12.030
Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036- 2045.
https://doi.org/10.1111/j.1572-0241.2007.01255.x
Sugumar A, Singh A, Pasricha PJ. A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. Clin Gastroenterol Hepatol. 2008;6(7):726-733.
https://doi.org/10.1016/j.cgh.2008.02.065
Quigley, EM. Cisapride: what wan we learn from the rise and fall of a prokinetic? J Dig Dis. 2011;12(3):147-156. https://doi.org/10.1111/j.1751-2980.2011.00491.x
Richards RD, Valenzuela GA, Davenport KG, Fisher KL, McCallum RW. Objective and subjective results of a randomized, double- blind, placebo-controlled trial using cisapride to treat gastroparesis. Dig Dis Sci. 43. 1993;38(5):811-816.
https://doi.org/10.1007/BF01295905
Rabine JC, Barnett JL. Management of the patient with gastroparesis. J Clin Gastroenterol. 2001;32(1): 11-18. https://doi.org/10.1097/00004836-200101000-00005
Mansi C, Borro P, Giacomini M, Biagini R, Mele MR, Pandolfo N, Savarino V. Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis. Aliment Pharmacol Ther. 2000;14(5):561-9.
https://doi.org/10.1046/j.1365-2036.2000.00742.x
McCallum RW, Lembo A, Esfandyari T, et al. TZP-102 Phase 2b Study Group. Phase 2b, randomized, double-blind 12-week studies of TZP-102, a ghrelin receptor agonist for diabetic gastroparesis. Neurogastroenterol Motil. 2013;25(11):e705-17.
https://doi.org/10.1111/nmo.12184
Camilleri M, Acosta A. A ghrelin agonist fails to show benefit in patients with diabetic gastroparesis: let’s not throw the baby out with the bath water. Neurogastroenterol Motil 2013;25(11):859-63.
https://doi.org/10.1111/nmo.12226
Shin A, Camilleri M, Busciglio I, Burton D, Smith SA, Vella A, Ryks M, Rhoten D, Zinsmeister AR. The ghrelin agonist RM-131 accelerates gastric emptying of solids and reduces symptoms in patients with type 1 diabetes mellitus. Clin Gastroenterol Hepatol. 2013;11(11):1453-1459.e4. https://doi.org/10.1016/j.cgh.2013.04.019
Vanormelingen C, Tack J, Andrews CN. Diabetic gastroparesis. Br Med Bull. 2013;105:213-230.
https://doi.org/10.1093/bmb/ldt003
Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, Lacy BE, DiBaise JK, Prather CM, Abraham BP, El-Serag HB, Moayyedi P, Herrick LM, Szarka LA, Camilleri M, Hamilton FA, Schleck CD, Tilkes KE, Zinsmeister AR. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology. 2015;149(2):340-9.e2.
https://doi.org/10.1053/j.gastro.2015.04.020
Skole KS, Panganamamula KV, Bromer MQ, Thomas P, Meilahn JE, Fisher RS, Parkman HP. Efficacy of gastric electrical stimulation for gastroparesis refractory to medical therapy: a single center experience. Am J Gastroenterol 2002;97(9):S48.
https://doi.org/10.1016/S0002-9270(02)04617-8
Abell TL, Van Cutsem E, Abrahamsson H, Huizinga JD, Konturek JW, Galmiche JP, Voeller G, Filez L, Everts B, Waterfall WE, Domschke W, Bruley des Varannes S, Familoni BO, Bourgeois IM, Janssens J, Tougas G. Gastric electrical stimulation in intractable symptomatic gastroparesis. Digestion. 2002;66(4):204-12.
https://doi.org/10.1159/000068359
Abell T, McCallum R, Hocking M, Koch K, Abrahamsson H, Leblanc I, Lindberg G, Konturek J, Nowak T, Quigley EM, Tougas G, Starkebaum W. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology. 2003;125(2):421-8.
https://doi.org/10.1016/S0016-5085(03)00878-3
Abell T, Lou J, Tabbaa M, Batista O, Malinowski S, Al-Juburi A. Gastric electric stimulation for gastroparesis improves nutritional parame- ters at short, intermediate, and long-term follow-up. J Parenter Enteral Nutr. 2003;27(4):277-81.
https://doi.org/10.1177/0148607103027004277
Tack J. The difficult patient with gastroparesis. Best Pract Res Clin Gastroenterol. 2007;21(3):379-91.
https://doi.org/10.1016/j.bpg.2007.01.002
Bhayani NH, Sharata AM, Dunst CM, Kurian AA, Reavis KM, Swanstrom LL. End of the road for a dysfunctional end organ: laparoscopic gastrectomy for refractory gastroparesis. J Gastrointest Surg. 2015;19(3):411-7.

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