Manejo de pacientes con enfermedad inflamatoria intestinal durante la pandemia de COVID-19d-19
DOI:
https://doi.org/10.22516/25007440.537Palabras clave:
COVID-19, SARS-Cov-2, enfermedad inflamatoria intestinalResumen
La pandemia causada por el virus SARS-CoV-2, originada en Wuhan, capital de la provincia de Hubei (China), se ha convertido en un desafío para la humanidad. Es un virus altamente contagioso; hasta el momento, la enfermedad por coronavirus (COVID-19) presenta una mortalidad global alrededor del 6 %, que es mayor en pacientes con comorbilidades. La enfermedad inflamatoria intestinal (EII) es una patología discapacitante, con daño tisular y alteración en la respuesta inmunológica, lo cual, asociado a los medicamentos inmunosupresores que se utilizan frecuentemente para su tratamiento, pone al paciente en riesgo de desarrollar infecciones y complicaciones. En esta revisión consideramos la interacción del virus SARS-CoV-2 con el tracto gastrointestinal y los potenciales mecanismos por los cuales un paciente con EII podría tener un riesgo incrementado de la infección por COVID-19. Adicionalmente, y a pesar de que no hay estudios clínicos publicados en pacientes con EII y COVID-19, damos recomendaciones basadas en opinión de expertos sobre el cuidado de pacientes con EII, con énfasis en su tratamiento y la realización segura de procedimientos endoscópicos, tanto para el paciente como para el personal de salud.
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Referencias bibliográficas
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implication for virus origins and receptor binding. Lancet 2020;395:565-574. https://doi.org/10.1016/S0140-6736(20)30251-8
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. https://doi.org/10.1056/NEJMoa2001017
World Health Organization [Internet]. Coronavirus. 2020 [acceso 15 de abril de 2020]. Disponible en: https://www.who.int/health-topics/coronavirus
Johns Hopkins University Coronavirus Resource Center [Internet]. Coronavirus COVID-19 Global Cases 2020 [acceso 15 de abril de 2020]. Disponible en: https://coronavirus.jhu.edu/map.html
van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564-1567. https://doi.org/10.1056/NEJMc2004973
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020; M20-0504. https://doi.org/10.1101/2020.02.02.20020016
Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARSCoV-2. Gastroenterology. 2020; S0016508520302821. https://doi.org/10.1053/j.gastro.2020.02.055
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020;382(10):929–936. https://doi.org/10.1056/NEJMoa2001191
Borges do Nascimento IJ, Cacic N, Abdulazeem HM, Caspar von Groote T, Jayarajah U, Weerasekara I, et al. Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis. J Clin Med. 2020;9(4):E941. https://doi.org/10.3390/jcm9040941
Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020. https://doi.org/10.1001/jama.2020.2648
Cheung KS, Hung I, Chang P, Lung KC, Tso E, Liu R, et al. Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. 2020. https://doi.org/10.1053/j.gastro.2020.03.065
Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel J-F. Ulcerative Colitis. Lancet. 2017;389(10080):1756-1770. https://doi.org/10.1016/S0140-6736(16)32126-2
Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn´s Disease. Lancet. 2017;389(10080):1741-1755. https://doi.org/10.1016/S0140-6736(16)31711-1
Ng SC, Shi HY, Hamidi N, Underwood FE, Whitney Tang W, Benchimol EL, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2018;390(10114):2769-2778. https://doi.org/10.1016/S0140-6736(17)32448-0
Kotze PG, Underwood F, Damiao AOMC, Ferraz JG, Saad-Hossne R, Toro M, et al. Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review. Clin Gastroenterol Hepatol. 2020;18(2):304-312. https://doi.org/10.1016/j.cgh.2019.06.030
Bonovas S, Fiorino G, Allocca M, Lytras T, Nikolopoulos GK, Peyrin-Biroulet L, et al. Biologic Therapies and Risk of Infection and Malignancy in Patients with Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis. Clin Gastroenterol Hepatol. 2016;14(10):1385–1397. https://doi.org/10.1016/j.cgh.2016.04.039
Govani SM, Higgins PD. Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD. J Crohns Colitis. 2010;4(4):444–9. https://doi.org/10.1016/j.crohns.2010.02.009
Wisniewski A, Kirchgesner J, Seksik Ph, Landman C, Bourrier A, Nion-Larmurier I, et al. Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines. United Eur. Gastroenterol. J. 2020;8(3):303-313. https://doi.org/10.1177/2050640619889763
Toruner M, Loftus EV, Harmsen WS, Zinsmeister AR, Orenstein R, Sandborn WJ, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology 2008;134(4):929–936. https://doi.org/10.1053/j.gastro.2008.01.012
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020. https://doi.org/10.1016/j.cell.2020.02.052
Monteleone G, Ardizzone S. Are patients with inflammatory bowel disease at increased risk for Covid-19 infection? J Crohns Colitis. 2020. https://doi.org/10.1093/ecco-jcc/jjaa061
Garg M, Royce SG, Tikellis C, Shallue C, Batu D, Velkoska E, et al. Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target? Gut. 2020;69(5):841–851. http://dx.doi.org/10.1136/gutjnl-2019-318512
Mao R, Liang J, Shen J, Ghosh S, Zhu LR, Yang H, et al. Implications of COVID-19 for patients with pre-existing digestive diseases. Lancet Gastroenterol Hepatol. 2020;5(5):426-428. https://doi.org/10.1016/S2468-1253(20)30076-5
Brenner EJ, Ungaro RC, Colombel JF, Kappelman MD. Surveillance Epidemiology of Coronavirus) Under Research Exclusion (SECURE-IBD) [acceso 15 de abril de 2020]. Database Public Data Update. Disponible en: https://www.covidibd.org
Fiorino G, Allocca M, Furfaro F, et al. Inflammatory bowel disease care in the COVID-19 pandemic era: the Humanitas, Milan experience. J Crohns Colitis. 2020. https://doi.org/10.1093/ecco-jcc/jjaa058
Rubin DT, Abreu MT, Rai V, Siegel CA; International Organization for the Study of Inflammatory Bowel Disease. Management of Patients with Crohn’s Disease and Ulcerative Colitis During the COVID-19 Pandemic: Results of an International Meeting. Gastroenterology. 2020; S0016-5085(20)30465-0. https://doi.org/10.1053/j.gastro.2020.04.002
World Health Organization [Internet]. Q&A on Coronaviruses [COVID-19]. [ acceso 15 de abril de 2020]. Disponible en: https://www.who.int/news-room/q-a-detail/q-a-coronaviruses
Danese S, Cecconi M, Spinelli A. Management of IBD during the COVID-19 outbreak: resetting clinical priorities. Nat Rev Gastroenterol Hepatol. 2020. https://doi.org/10.1038/s41575-020-0294-8
Shang L, Zhao J, Hu Y, Du R, Cao B. On the use of corticosteroids for 2019-nCoV pneumonia. Lancet. 2020; 395:683–4. https://doi,org/10.1016/S0140-6736(20)30361-5
Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission [published online ahead of print, 2020 Mar 3]. Gastroenterology. 2020. https://doi.org/10.1053/j.gastro.2020.02.054
Chen L, Lou J, Bai Y, Wang M. COVID-19 Disease with Positive Fecal and Negative Pharyngeal and Sputum Viral Tests [published online ahead of print, 2020 Mar 20]. Am J Gastroenterol. 2020. https://doi.org/10.14309/ajg.0000000000000610
Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020. https://doi,org/10.1038/s41586-020-2196-x
Sultan S, Lim JK, Altayar O, Davitkov P, Feuerstein JD, Siddique SM, et al. AGA Institute Rapid Recommendations for Gastrointestinal Procedures During the COVID-19 Pandemic. Gastroenterology. 2020. https://doi.org/10.1053/j.gastro.2020.03.072
Repici A, Maselli R, Colombo M, Spadaccini M, Anderloni A, Carrara S, et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. Gastrointest Endosc. 2020. https://doi.org/10.1016/j.gie.2020.03.019
Sociedad Española de Endoscopia Digestiva (SEED). Recomendaciones de la SEED: Protección en Unidades de Endoscopia frente al COVID-19 [Internet] [acceso 15 de abril de 2020]. Disponible en: https://wseed.es/images/site/guia_clinica/2020/RecomendacionesSEED_ProteccionUnidadesEndoscopia_Coronavirus.pdf
Zhang Y, Zhang X, Liu L, Wang H, Zhao Q. Suggestions for infection prevention and control in digestive endoscopy during current 2019-nCoV pneumonia outbreak in Wuhan, Hubei province, China. Endoscopy. 2020;52(4):312–314. https://doi.org/10.1055/a-1128-4313
Otero W, Gómez M, Ángel LA, Ruiz O, Marulanda H, Riveros J, et al. Procedimientos endoscópicos y pandemia COVID-19 Consideraciones básicas. Rev Colomb Gastroenterol. 2020;35(1):65-75. https://doi.org/10.22516/25007440.526
Rubin DT, Feuerstein JD, Wang AY, Cohen RD. AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary. Gastroenterology. 2020. https://doi.org/10.1053/j.gastro.2020.04.012

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