Esophageal Leukoplakia and Its Clinical Significance: Does It Imply Risk?

Authors

DOI:

https://doi.org/10.22516/25007440.1279

Keywords:

Leukoplakia, esophagus, esophageal diseases, epidermolytic hyperkeratosis, endoscopy, squamous cell carcinoma

Abstract

Esophageal leukoplakia is an extremely rare condition. It typically occurs in patients who smoke, frequently consume alcohol, or have chronic mucosal irritation from gastroesophageal reflux. Endoscopically, well-circumscribed whitish plaques are commonly observed in the middle or distal third of the esophagus. These lesions can be easily mistaken for glycogenic acanthosis, esophageal papilloma, eosinophilic esophagitis, or Candida esophagitis. Timely recognition and management are essential, as esophageal leukoplakia is considered a precursor to squamous cell carcinoma.

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Author Biographies

Aldair José Chaar-Hernández, Pontificia Universidad Javeriana

Fellow de Gastroenterología. Departamento de Gastroenterología y Endoscopia, Hospital Universitario San Ignacio, Bogotá, Colombia.

Hernando José Vergara-Segrera, Pontificia Universidad Javeriana

Especialista en Gastroenterología y Profesor clínico adjunto de Gastroenterología. Departamento de Gastroenterología y Endoscopia, Hospital Universitario San Ignacio. Bogotá, Colombia.

Jesús Antonio Rodríguez-Fajardo, Pontificia Universidad Javeriana

Especialista en Gastroenterología y Profesor clínico adjunto de Gastroenterología. Departamento de Gastroenterología y Endoscopia, Hospital Universitario San Ignacio. Bogotá, Colombia.

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Figura 1. Exámenes del caso clínico. A, B y C. EGD que muestra una lesión de 30 mm en el esófago distal caracterizada como placa blanquecina bien delimitada con mucosa circundante normal y sugestiva de leucoplasia. D. Leucoplasia elevada con ácido hialurónico, solución salina y azul de metileno antes de la disección vista a través de Cap. E y F. Disección submucosa endoscópica de leucoplasia esofágica. Lecho de resección. Imágenes propiedad de los autores.

Published

2025-09-30

How to Cite

Chaar Hernandez, A. J., Vergara Segrera, H. J., & Rodriguez Fajardo , J. A. (2025). Esophageal Leukoplakia and Its Clinical Significance: Does It Imply Risk?. Revista Colombiana De Gastroenterología, 40(3), 367–371. https://doi.org/10.22516/25007440.1279