Collagenous Gastritis: An Unusual Cause of Anemia in Young Patients
DOI:
https://doi.org/10.22516/25007440.1264Keywords:
Gastritis, anemia, collagenous colitis, celiac diseaseAbstract
Collagenous gastritis (CG) is a rare condition that, in most cases, presents with severe iron-deficiency anemia or recurrent abdominal pain. It is characterized by increased collagen deposition in the subepithelial mucosa, associated with inflammatory infiltrates in the lamina propria. Similar histological findings can be observed in collagenous enterocolitis. The pathophysiology and prognosis of the disease are not yet fully understood, and clinical presentation may vary according to age group.
This report describes a 15-year-old female patient referred by hematology for evaluation of chronic anemia, accompanied by asthenia, adynamia, pica, and abdominal pain. Esophagogastroduodenoscopy revealed severe mucosal alterations in the gastric body, and thorough pathological review confirmed the diagnosis of collagenous gastritis.
Histologically observed collagen deposits may be related to a generalized disease affecting different areas of the gastrointestinal tract. In light of this case, a review of the available literature was conducted.
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Genta RM, Turner KO, Morgan CJ, Sonnenberg A. Collagenous gastritis: Epidemiology and clinical associations. Dig Liver Dis. 2021;53(9):1136-1140. https://doi.org/10.1016/j.dld.2021.03.010
Käppi T, Wanders A, Wolving M, Lingblom C, Davidsson Bården B, et al. Collagenous gastritis in children: Incidence, disease course, and associations with autoimmunity and inflammatory markers. Clin Transl Gastroenterol. 2020;11(8):e00219. https://doi.org/10.14309/ctg.0000000000000219
Liu Y, Luo YY, Gu WZ, Tang HF, Chen J. [Collagenous gastritis in Chinese]. Zhonghua Er Ke Za Zhi. 2022;60(12):1339-1341. https://doi.org/10.3760/cma.j.cn112140-20220309-00186
Isoldi S, Viola F, Cucchiara S, Dilillo A, Iorfida D, Testi AM, et al. Management of collagenous gastritis in children: Case series and literature review. Indian J Gastroenterol. 2024;43(3):567-577. https://doi.org/10.1007/s12664-023-01472-3
Arnason T, Brown IS, Goldsmith JD, Anderson W, O’Brien BH, Wilson C, et al. Collagenous gastritis: A morphologic and immunohistochemical study of 40 patients. Mod Pathol. 2015;28(4):533-544. https://doi.org/10.1038/modpathol.2014.119
Müller S, Neureiter D, Stolte M, Verbeke C, Heuschmann P, Kirchner T, et al. Tenascin: A sensitive and specific diagnostic marker of minimal collagenous colitis. Virchows Arch. 2001;438(5):435-441. https://doi.org/10.1007/s004280000375
Nielsen OH, Riis LB, Danese S, Bojesen RD, Soendergaard C. Proximal collagenous gastroenteritides: Clinical management. A systematic review. Ann Med. 2014;46(5):311-317. https://doi.org/10.3109/07853890.2014.899102
Kori M, Cohen S, Levine A, Givony S, Sokolovskaia-Ziv N, Melzer E, et al. Collagenous gastritis: A rare cause of abdominal pain and iron-deficiency anemia. J Pediatr Gastroenterol Nutr. 2007;45(5):603-606. https://doi.org/10.1097/MPG.0b013e31803cd545
Brain O, Rajaguru C, Warren B, Booth J, Travis S. Collagenous gastritis: Reports and systematic review. Eur J Gastroenterol Hepatol. 2009;21(12):1419-1424. https://doi.org/10.1097/MEG.0b013e32832770fa
Matta J, Alex G, Cameron DJS, Chow CW, Hardikar W, Heine RG. Pediatric collagenous gastritis and colitis: A case series and review of the literature. J Pediatr Gastroenterol Nutr. 2018;67(3):328-334. https://doi.org/10.1097/MPG.0000000000001975
Ma C, Park JY, Montgomery EA, Arnold CA, McDonald OG, Liu TC, et al. A comparative clinicopathologic study of collagenous gastritis in children and adults. Am J Surg Pathol. 2015;39(6):802-812. https://doi.org/10.1097/PAS.0000000000000441
Leung ST, Chandan VS, Murray JA, Wu TT. Collagenous gastritis. Am J Surg Pathol. 2009;33(5):788-798. https://doi.org/10.1097/PAS.0b013e318196a67f
Kozai L, Tan A, Nebrejas KE, Warashina C, Nishimura Y. Collagenous gastritis is an underdiagnosed cause of anemia and abdominal pain: Systematic scoping review. Dig Dis Sci. 2023;68(7):3103-3114. https://doi.org/10.1007/s10620-023-07938-w
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