Eradication of Helicobacter pylori with First-Line Treatment at a High-Complexity Hospital in Southwestern Colombia
DOI:
https://doi.org/10.22516/25007440.1229Keywords:
Helicobacter pylori, Eradication, Breath test, Microbial resistance, Treatment adherenceAbstract
Introduction and Objectives: Confirming the eradication of Helicobacter pylori is essential due to increasing antimicrobial resistance to various treatment regimens. The primary objective of this study is to determine the eradication rate of H. pylori using the carbon-14 (14C) urea breath test.
Materials and Methods: A cross-sectional study with an analytical component was conducted by retrospectively reviewing medical records of patients who received eradication treatment for H. pylori and subsequent confirmation of eradication through the 14C urea breath test. The study was carried out at Hospital Universitario Fundación Valle del Lili between January 2019 and June 2022.
Results: A total of 360 patients met the inclusion criteria. Women represented 66.9% of the sample, with a median age of 51 years (interquartile range [IQR]: 39–61). A negative 14C urea breath test result was obtained in 84.4% of cases, with a median interval of eight weeks (IQR: 5–12) between the end of treatment and test performance. Almost all patients received 14 days of treatment.
Conclusions: An acceptable eradication rate was observed in our setting, even with the standard triple therapy, which remains the most commonly used regimen. Antimicrobial susceptibility studies are needed to guide treatments based on local epidemiology.
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